17β-Estradiol induces changes in cytokine levels in head kidney and blood of juvenile sea bass (Dicentrarchus labrax, L., 1758).
Identifieur interne : 003335 ( Main/Exploration ); précédent : 003334; suivant : 00333617β-Estradiol induces changes in cytokine levels in head kidney and blood of juvenile sea bass (Dicentrarchus labrax, L., 1758).
Auteurs : Frauke Seemann [France] ; Thomas Knigge ; Béatrice Rocher ; Christophe Minier ; Tiphaine MonsinjonSource :
- Marine environmental research [ 1879-0291 ]
English descriptors
- KwdEn :
- Animals, Bass (growth & development), Bass (metabolism), Cytokines (blood), Cytokines (metabolism), Dose-Response Relationship, Drug, Environmental Exposure, Environmental Monitoring, Estradiol (metabolism), Estrogens (metabolism), Fish Proteins (blood), Fish Proteins (metabolism), Gene Expression Regulation, Head Kidney (drug effects), Head Kidney (growth & development), Head Kidney (metabolism), Immune System (growth & development), Real-Time Polymerase Chain Reaction, Time Factors, Water Pollutants, Chemical (metabolism).
- MESH :
- chemical , blood : Cytokines, Fish Proteins.
- drug effects : Head Kidney.
- growth & development : Bass, Head Kidney, Immune System.
- metabolism : Bass, Cytokines, Estradiol, Estrogens, Fish Proteins, Head Kidney, Water Pollutants, Chemical.
- Animals, Dose-Response Relationship, Drug, Environmental Exposure, Environmental Monitoring, Gene Expression Regulation, Real-Time Polymerase Chain Reaction, Time Factors.
Abstract
The cytokine network is involved in the immune system communication. As estrogens influence the cytokine expression in mammals, this study investigated the impact of exogenous estrogenic pollutants on selected cytokines in Dicentrarchus labrax. The gene expression of Interleukin 6, Tumour Necrosis Factor α, Transforming Growth Factor β1 and Interleukin 1β was assessed and accomplished with protein measurements in the blood for the last two. Impacts through 17β-estradiol mainly occurred at the beginning of organ regionalisation, thus falling together with a developmentally induced increase of Interleukin 1β and Tumour Necrosis Factor α gene expression in 102 dph fish. 17β-estradiol depressed this modification after 35 days of exposure and the cytokine gene expression tended to be generally down-regulated independently of the 17β-estradiol concentrations after 56 days of exposure. This impact was confirmed at the protein level, showing that 17β-estradiol affects the fine control of the cytokine network in sea bass.
DOI: 10.1016/j.marenvres.2013.03.003
PubMed: 23602341
Affiliations:
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Milieux Aquatiques (LEMA), SFR SCALE 4116, Université du Havre, 25 Rue Philippe Lebon, 76058 Le Havre Cedex, France. frauke.seemann@univ-lehavre.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Écotoxicologie - Milieux Aquatiques (LEMA), SFR SCALE 4116, Université du Havre, 25 Rue Philippe Lebon, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Knigge, Thomas" sort="Knigge, Thomas" uniqKey="Knigge T" first="Thomas" last="Knigge">Thomas Knigge</name></author><author><name sortKey="Rocher, Beatrice" sort="Rocher, Beatrice" uniqKey="Rocher B" first="Béatrice" last="Rocher">Béatrice Rocher</name></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></author><author><name sortKey="Monsinjon, Tiphaine" sort="Monsinjon, Tiphaine" uniqKey="Monsinjon T" first="Tiphaine" last="Monsinjon">Tiphaine Monsinjon</name></author></analytic><series><title level="j">Marine environmental research</title><idno type="eISSN">1879-0291</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bass (growth & development)</term><term>Bass (metabolism)</term><term>Cytokines (blood)</term><term>Cytokines (metabolism)</term><term>Dose-Response Relationship, Drug</term><term>Environmental Exposure</term><term>Environmental Monitoring</term><term>Estradiol (metabolism)</term><term>Estrogens (metabolism)</term><term>Fish Proteins (blood)</term><term>Fish Proteins (metabolism)</term><term>Gene Expression Regulation</term><term>Head Kidney (drug effects)</term><term>Head Kidney (growth & development)</term><term>Head Kidney (metabolism)</term><term>Immune System (growth & development)</term><term>Real-Time Polymerase Chain Reaction</term><term>Time Factors</term><term>Water Pollutants, Chemical (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term><term>Fish Proteins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Head Kidney</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Bass</term><term>Head Kidney</term><term>Immune System</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bass</term><term>Cytokines</term><term>Estradiol</term><term>Estrogens</term><term>Fish Proteins</term><term>Head Kidney</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Environmental Exposure</term><term>Environmental Monitoring</term><term>Gene Expression Regulation</term><term>Real-Time Polymerase Chain Reaction</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cytokine network is involved in the immune system communication. As estrogens influence the cytokine expression in mammals, this study investigated the impact of exogenous estrogenic pollutants on selected cytokines in Dicentrarchus labrax. The gene expression of Interleukin 6, Tumour Necrosis Factor α, Transforming Growth Factor β1 and Interleukin 1β was assessed and accomplished with protein measurements in the blood for the last two. Impacts through 17β-estradiol mainly occurred at the beginning of organ regionalisation, thus falling together with a developmentally induced increase of Interleukin 1β and Tumour Necrosis Factor α gene expression in 102 dph fish. 17β-estradiol depressed this modification after 35 days of exposure and the cytokine gene expression tended to be generally down-regulated independently of the 17β-estradiol concentrations after 56 days of exposure. This impact was confirmed at the protein level, showing that 17β-estradiol affects the fine control of the cytokine network in sea bass.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement><orgName><li>Université du Havre</li></orgName></list><tree><noCountry><name sortKey="Knigge, Thomas" sort="Knigge, Thomas" uniqKey="Knigge T" first="Thomas" last="Knigge">Thomas Knigge</name><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name><name sortKey="Monsinjon, Tiphaine" sort="Monsinjon, Tiphaine" uniqKey="Monsinjon T" first="Tiphaine" last="Monsinjon">Tiphaine Monsinjon</name><name sortKey="Rocher, Beatrice" sort="Rocher, Beatrice" uniqKey="Rocher B" first="Béatrice" last="Rocher">Béatrice Rocher</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Seemann, Frauke" sort="Seemann, Frauke" uniqKey="Seemann F" first="Frauke" last="Seemann">Frauke Seemann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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